Microsoft Defender AV must be configured to only send safe samples for MAPS telemetry.
This policy setting configures behavior of samples submission when opt-in for MAPS telemetry is set. Possible options are:
(0x0) Always prompt
(0x1) Send safe samples automatically
(0x2) Never send
(0x3) Send all samples automatically
How this relates to the STIG checklist: STIG vs SCAP benchmark.