Microsoft Defender AV must be configured to perform a weekly scheduled scan.
This policy setting allows specifying the day of the week on which to perform a scheduled scan. The scan can also be configured to run every day or to never run at all. This setting can be configured with the following ordinal number values:
(0x0) Every Day
(0x1) Sunday
(0x2) Monday
(0x3) Tuesday
(0x4) Wednesday
(0x5) Thursday
(0x6) Friday
(0x7) Saturday
(0x8) Never (default)
If this setting is enabled, a scheduled scan will run at the frequency specified. If this setting is disabled or not configured, a scheduled scan will run at a default frequency.
How this relates to the STIG checklist: STIG vs SCAP benchmark.