Microsoft Defender AV must be configured block Office applications from creating executable content.
This rule targets typical behaviors used by suspicious and malicious add-ons and scripts (extensions) that create or launch executable files. This is a typical malware technique. Extensions will be blocked from being used by Office apps. Typically these extensions use the Windows Scripting Host (.wsh files) to run scripts that automate certain tasks or provide user-created add-on features.
How this relates to the STIG checklist: STIG vs SCAP benchmark.