Microsoft Defender AV must be configured to block execution of potentially obfuscated scripts.
Malware and other threats can attempt to obfuscate or hide their malicious code in some script files. This rule prevents scripts that appear to be obfuscated from running. It uses the AntiMalwareScanInterface (AMSI) to determine if a script is potentially obfuscated and then blocks such a script or blocks scripts when an attempt is made to access them.
How this relates to the STIG checklist: STIG vs SCAP benchmark.