Microsoft Defender AV must enable extended cloud check.
When Microsoft Defender Antivirus finds a suspicious file, it can prevent the file from running while it queries the Microsoft Defender Antivirus cloud service.
The default period that the file is blocked is 10 seconds. Extending the cloud block timeout period can help ensure there is enough time to receive a proper determination from the Microsoft Defender Antivirus cloud service.
How this relates to the STIG checklist: STIG vs SCAP benchmark.