Microsoft Defender AV must enable script scanning.
Always-on protection consists of real-time protection, behavior monitoring, and heuristics to identify malware based on known suspicious and malicious activities. These activities include events, such as processes making unusual changes to existing files, modifying or creating automatic startup registry keys and startup locations (also known as autostart extensibility points, or ASEPs), and other changes to the file system or file structure.
How this relates to the STIG checklist: STIG vs SCAP benchmark.