Launching programs and files in IFRAME must be disallowed (Internet zone).
This policy setting allows you to manage whether applications may be run and files may be downloaded from an IFRAME reference in the HTML of the pages in this zone. Launching of programs in IFRAME must have a level of protection based upon the site being accessed. If you enable this policy setting, applications can run and files can be downloaded from IFRAMEs on the pages in this zone without user intervention. If you disable this setting, users are prevented from running applications and downloading files from IFRAMEs on the pages in this zone.
How this relates to the STIG checklist: STIG vs SCAP benchmark.