Custom user interface (UI) code must be blocked from loading in all Office applications.
This policy setting controls whether Office 365 ProPlus applications load any custom user interface (UI) code included with a document or template. Office 365 ProPlus allows developers to extend the UI with customization code that is included in a document or template.
If this policy setting is enabled, Office 365 ProPlus applications cannot load any UI customization code included with documents and templates.
If this policy setting is not configured or disabled, Office 365 ProPlus applications load any UI customization code included with a document or template when opening it.
How this relates to the STIG checklist: STIG vs SCAP benchmark.