Files in unsafe locations must be opened in Protected view in PowerPoint.
This policy setting determines whether files located in unsafe locations will open in Protected View. If unsafe locations have not been specified, only the "Downloaded Program Files" and "Temporary Internet Files" folders are considered unsafe locations. If enabling this policy setting, files located in unsafe locations do not open in Protected View. If disabling or not configuring this policy setting, files located in unsafe locations open in Protected View.
How this relates to the STIG checklist: STIG vs SCAP benchmark.