Windows 10 information systems must use BitLocker to encrypt all disks to protect the confidentiality and integrity of all information at rest.
If data at rest is unencrypted, it is vulnerable to disclosure. Even if the operating system enforces permissions on data access, an adversary can remove non-volatile memory and read it directly, thereby circumventing operating system controls. Encrypting the data ensures that confidentiality is protected even when the operating system is not running.
How this relates to the STIG checklist: STIG vs SCAP benchmark.