The x86 Ctrl-Alt-Delete key sequence in TOSS must be disabled if a graphical user interface is installed.
A locally logged-on user, who presses Ctrl-Alt-Delete when at the console, can reboot the system. If accidentally pressed, as could happen in the case of a mixed OS environment, this can create the risk of short-term loss of availability of systems due to unintentional reboot. In a graphical user environment, risk of unintentional reboot from the Ctrl-Alt-Delete sequence is reduced because the user will be prompted before any action is taken.
How this relates to the STIG checklist: STIG vs SCAP benchmark.